After many great years in academia, I finally decided in October of last year to resign from my position as tenured assistant professor. As of February of this year, I proudly walk the earth as an independent engineer.
It has taken me two years of thinking to reach this decision.
I started re-evaluating my life in academia two years ago after a review-for-promotion (See the “oral defence” bullet. :)) process that resulted in a “not quite yet” judgement. It took this long to make my decision, because it was actually going quite well. I had tenure, the holy grail (well, the first of a number of them) for many academics. I had built up and was heading the TU Delft Medical Visualization research group. I was fortunate to attract the best postgraduate students and Ph.D. candidates. My research proposals were successful, so I had money to explore exciting new research avenues. My h-index was (slowly) going in the right direction. Even my teaching was more than occasionally positively received. :)